Adalat® in the Asian Pacific Region by Y. Nakamura, H. Miyashita, O. Iimura, K. Ueda, T. Sugimoto,

By Y. Nakamura, H. Miyashita, O. Iimura, K. Ueda, T. Sugimoto, Y. Toyama (auth.), Prof.Dr. David T. Kelly (eds.)

These are the complaints of the 3rd Asian Pacific Adalat Symposium. the 1st was once held in Tokyo in 1982 and the second one in Sydney in 1985. We have been honoured that the past due Dr. Sukaman and his colleagues have been capable of host this 3rd symposium in Jakarta. This assembly used to be designed to give a contribution to and to advertise overseas collaboration in cardiovascular study, and to aid advertise extra wisdom and knowing in regards to the therapy of vascular affliction within the Asian Pacific region. Nifedipine was once initially investigated within the mid-1960s through Prof. Fleckenstein. His first effects confirmed this drug used to be a robust calcium antagonist which altered excitation contraction. at present, there has been a swift improvement of information in regards to the pathophysiology of ischaemic middle illness, and therefore the $64000 pharmacological paintings on calcium antagonists resembling nifedipine paralleled and complimented the more moderen knowing of coronary body structure in guy. very quickly so much treatment was once designed to minimize myocardial oxygen intake and demand.

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20. e. 21. AR. 22. a 23. S. 24. b M F F F M F F M M M M M M M F M M M F M M M M F Sex C, Control; N, nifedipine. a Insignificant angiography. 0 C 3 b Angiography with positive ergonovine test. 0 0 C 0 Stage Table 4. ,~ > 0- ~ ? 00 MEAN STSEGMENT DEPRESSION (mm) 14 13 7 3 I 14 14 14 STAGES; 0 14 14 DURING EXERCISE 12 III 6 IV 4 2 min 14 AFTER EXERCISE 5 min 14 8 min 14 --~--l_-l __ J//-----t---l-_l-_l 14 Fig. 1. 5 I I I I I I I I ~ z ...... o a' ~ s' I;,;' ... 0- ::s po S' po (JQ 'E;-" ~ [/J S' 0' ::s 2' on ('\) ...

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