Adjuvant Therapy of Primary Breast Cancer VI by E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn,

By E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn, Richard D. Gelber Ph.D, Prof. Dr. med. Aron Goldhirsch, Priv.-Doz. Dr. med. Beat Thürlimann (eds.)

This quantity offers an up to date survey of present laboratory and, mostly, scientific learn at the diagnostic and healing procedures in fundamental breast melanoma. The chapters derive from the invited professional lectures offered on the sixth overseas convention on fundamental Breast melanoma held in St. Gallen, Switzerland, in February 1998. the global breast melanoma group has been eagerly waiting for this quantity and its consensus platform and suggestions. there is not any substitute to this assembly and publication within the box of adjuvant remedy of fundamental breast cancer.

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Extra resources for Adjuvant Therapy of Primary Breast Cancer VI

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1997). Finally, the new SERM LY353381· HCI has been reported to be a potent estrogen antagonist in breast and uterus, an estrogen agonist in bone and cardiovascular tissues, and to be very effective in inhibiting mammary carcinogenesis in rats (Sporn et al. 1997). Conclusions Prevention is clearly one of the doors we have to go through in order to arrive to the unfolding and solving of the cancer problem. Today we know much more about the various aspects of the long and complex carcinogenic process leading to that final entity which is breast cancer.

There is some reason to believe that, as in endometrial cancer, the risk of developing breast cancer associated with ERT may be higher than the actual risk of dying from it. In breast cancer, possible explanations for this have been suggested by several authors who have shown that breast cancers developing in women on ERT/HRT may be smaller or have a better grade or better differentiation (Harding et al. 1996; Bonnier et al. 1995). Paradoxically, however, it has been suggested that there are also fewer ER+ tumors in this setting (Harding et al.

Proc Am Soc Clin Onco117:109a Paganini-Hill A, Henderson VW (1996) Estrogen replacement therapy and risk of Alzheimer disease. Arch Intern Med 156:2213-2217 PEPI Trial (1995) Effects of estrogen or estrogen/progestin regimes on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) trial. JAMA 273:199-208 Pike MC, Peters RK, Cozen W, Probst-Hensch NM (1997) Estrogen-progestin replacement therapy and endometrial cancer. J Nat! Cancer Inst 89:1110-1116 Psaty BM, Heckbert SR, Atkins D, Lemaitre R, Koepsell TD, Wahl PW, Siscovick DS, Wagner EH (1994) The risk of myocardial infarction associated with the combined use of estrogen and progestins in postmenopausal women.

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