After the genome : a language for our biotechnological by Michael J. Hyde, James A. Herrick

By Michael J. Hyde, James A. Herrick

Technology, rhetoric, and conversing concerning the post-human future.

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Long-term follow-up is also likely to be extensive in any study involving the implantation of organs or tissues regenerated ex vivo, to ensure that success or failure can be determined in functional terms. Only long-term follow-up may be able to determine whether the experimental intervention is “working” when it is difficult to know when success or failure should be declared. For example, when, if ever, can a partial regeneration can be deemed successful? The first patient-subjects in early-stage regenerative medicine research will have important roles in defining and refining functionality, and thus helping to define both failure and success.

66 in a rodent model, the preserved ECM architecture of a heart, including walls, valves, and blood vessels, was perfused with harvested endothelial cells, and then injected with neonatal cardiac cells. 69 Looking forward to human studies, the lack of available autologous scaffolding for these solid organs represents a significant limitation. However, semi-xenotransplantation, in which the decellularized donor scaffold is an animal source yet the cells used to populate it are obtained from the human patient-subject, may represent a solution.

Kidney failure provides an example of how regenerative medicine technologies sharing these characteristics could not only shift consensus about medically indicated intervention but also, in consequence, alter current medical and social understanding of fundamental concepts like prevention and treatment, normal and abnormal. When an individual’s kidneys fail to function, the available treatments include dialysis and transplantation. 74 it is obvious that total lack of kidney function counts as kidney failure.

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